arxiv.org
It has been previously shown that strains of cannabis with high levels of THC and low levels of CBD can cause increased psychiatric effects, including paranoia, anxiety and addictive-behaviours, but why that was occurring was not fully understood. Steven Laviolette, PhD, and his research team used rats to investigate the role of a molecule in the brain's hippocampus called extracellular-signal regulated kinase (ERK) which triggers the neuropsychiatric effects of THC. Laviolette, a professor at Western's Schulich School of Medicine & Dentistry. The research, published in the Journal of Neuroscience demonstrates that rats that were given THC had higher levels of activated ERK, showed more anxiety behaviours and were more sensitive to fear-based learning. Rats that were given both CBD and THC acted like the control rats: they had normal levels of activated ERK, less anxiety behaviours, and were less sensitive to fear-based learning. Based on these results, this site the research team proposes that CBD blocks the ability of THC to overstimulate the ERK pathway in the hippocampus and thus prevent its negative side-effects. PhD Candidate and Vanier Scholar Roger Hudson, [TerraPro CBD](https://tenis.caracassportsclub.com/index.php?action=profile
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Cannabis Study Reveals how CBD Offsets the Psychiatric Side effects of THC
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